L’oléocanthal tue les cellules cancéreuses en 30 minutes

L’oléocanthal tue les cellules cancéreuses en 30 minutes

C’est ce qu’a mis en évidence tout récemment une équipe américaine de l’Université Rutgers et du Hunter College de la City University of New York (février 2015). Ces chercheurs émettent l’hypothèse que l’oléocanthal pénètre à l’intérieur des cellules cancéreuses et détruit les lysosomes, plus gros et plus fragiles dans les cellules cancéreuses que dans les cellules saines. Ainsi, la cellule «malade» finit par mourir. Les cellules saines, elles, demeurent intactes.

Absract :

(-)-Oleocanthal (OC), a phenolic compound in extra virgin olive oil (EVOO), has been implicated in the health benefits associated with diets rich in EVOO. We investigated the effect of OC on human cancer cell lines in culture. Amazingly, OC induced cell death in all cancer cells examined – as rapidly as 30 minutes after treatment in the absence of serum. OC treatment of non-transformed cells suppressed proliferation, but did not cause cell death. OC induced both primary necrotic and apoptotic cell death via induction of lysosomal membrane permeabilization (LMP). We provide evidence that OC promotes LMP by inhibiting acid sphingomyelinase (ASM) activity, which destabilizes the interaction between proteins necessary for lysosomal membrane stability. The data presented here indicates that cancer cells having fragile lysosomal membranes – as compared to non-cancerous cells – are susceptible to lysosomotropic agent-induced cell death. Therefore, targeting lysosomal membrane stabiltiy represents a novel approach to induce cancer-specific cell death.

2015-04-16-oleocanthal-tue-cancer
2015-04-16-oleocanthal-tue-cancer
2015-04-16-oleocanthal-tue-cancer.pdf
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