Les effets bénéfiques d’un concentré de tomates hydrosoluble sur la fonction plaquettaire et la réduction des thromboses : une étude clinique en double aveugle randomisée

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[wpfilebase tag=file id=106 /]Background: Aqueous extracts from tomatoes display a range of antiplatelet activities in vitro. We previously showed that the active components also alter ex vivo platelet function in persons with a high response to ADP agonist.

Objective: The objective was to evaluate the suitability of a tomato extract for use as a dietary supplement to prevent platelet activation.

Design: A randomized, double-blinded, placebo-controlled crossover study was conducted in 90 healthy human subjects selected for normal platelet function. Changes from baseline hemostatic function were measured 3 h after consumption of extract-enriched or control supplements.

Results: Significant reductions in ex vivo platelet aggregation induced byADPand collagen were observed 3 h after supplementation with doses of tomato extract equivalent to 6 (6TE) and 2 (2TE) tomatoes [3 mol ADP/L: 6TE (high dose), 21.3%; 2TE (low dose), 12.7%; P  0.001; 7.5 mol ADP/L: 6TE, 7.8%, 2TE, 7.6%; P0.001; 3 mg collagen/L: 6TE,17.5%; 2TE,14.6%; P  0.007]. No significant effects were observed for control supplements. A dose response to tomato extract was found at low levels of platelet stimulation. Inhibition of platelet function was greatest in a subgroup with the highest plasma homocysteine (P  0.05) and C-reactive protein concentrations (P  0.001).

Conclusion: As a functional food or dietary supplement, tomato extract may have a role in primary prevention of cardiovascular disease by reducing platelet activation, which could contribute to a reduction in thrombotic events.

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