Oleuropein, a non-toxic olive iridoid, is an anti-tumor agent and cytoskeleton disruptor

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Oleuropein, a non toxic secoiridoid derived from the olive tree, is a powerful antioxidant and anti angiogenic agent. Here, we show it to be a potent anti cancer compound, directly disrupting actin filaments in cells and in a cell free assay. Oleuropein inhibited the proliferation and migration of advanced grade human tumor cell lines in a dose responsive manner. In a novel tube disruption assay, Oleuropein irreversibly rounded cancer cells, preventing their replication, motility, and invasiveness; these effects were revers ible in normal cells. When administered orally to mice that developed spontaneous tumors, Oleuropein completely regressed tumors in 9 12 days. When tumors were resected prior to complete regression, they lacked cohesiveness and had a crumbly consistency. No viable cells could be recovered from these tumors. These observations elevate Oleuropein from a non toxic antioxidant into a potent anti tumor agent with direct effects against tumor cells. Our data may also explain the cancer protective effects of the olive rich Med iterranean diet.

 

Castelon Tumeur  HDT
Castelon Tumeur HDT
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